Award Notices

September 2017

MII Award Projects

These Maryland Innovation Initiative awards were given through the Innovation Commercialization Program, which provides funding to support the commercialization of qualified university technologies at two distinct stages: pre-commercial technology validation and commercialization planning (Phase I & 2 combined), and early-stage product development (company formation) (Phase III).

FUNDED COMPANIES

Accelevir Diagnostics, LLC
- Developing a novel test to measure latent virus in HIV-1 infected patients. Licensed technology from Johns Hopkins University.

Anacrusis, Inc.
- Developing an App called “Read Ahead” for Sight-Reading at the piano. Licensed technology from Johns Hopkins University.

Analytical Informatics
- Creating a suite of software based tools designed to improve quality and efficiency in health care. Licensed technology from University of Maryland Baltimore.

Aqua Animal Health
- Developing a Myostatin inhibitor for aquaculture which will improve feeding efficiency, accelerate growth, increase filet size, and increase fry (newly hatched fish) and fingerling survival rates. Licensed technology from Johns Hopkins University in collaboration with University of Maryland, Baltimore.

AsclepiX Therapeutics
- Developing a novel biomimetic peptide for the treatment of Macular Edema. Licensed technology from Johns Hopkins University.

Ashvattha Therapeutics, LLC
- Development of novel therapies for orphan pediatric brain disorders. Licensed technology from Johns Hopkins University.

Avasys, LLC
- Development of an improved luer access device (LAD) (SureFlow) designed to reduce the risk of infections associated with indwelling central venous catheters. Licensed technology from Johns Hopkins University.

Baton
- Develop Baton: A web-based collaboration tool that enables care teams to securely collaborate in real time. Licensed technology from Johns Hopkins University.

Biomecite Diagnostics, LLC
- Developing a microbiome diagnostic for inflammatory bowel disease. Licensed technology from University of Maryland, Baltimore.

CardioSolv Ablation Technologies, Inc.
- Developing software validation for regulatory compliance in simulation-guided ablation. Licensed technology from Johns Hopkins University.

Cellth Systems, LLC
- Developing microfluidic tethering of non-adherent tumor cells to optimize drug treatment for epithelial cancers. Licensed technology from University of Maryland Baltimore.

CoapTech, LLC.
- Design, manufacture and test pre-commercial Coaptive Ultrasound Gastrostomy (CUG) products for use in gastrostomy tube insertions. Licensed technology from University of Maryland, Baltimore.

CoolStride, LLC
- Developing a cooled prosthetic liner to reduce heat and sweat issues for amputees. Licensed technology from Johns Hopkins University.

CykloBurn Technologies, LLC
- Developing a low emission combustion system that will convert biomass into energy. Technology licensed from Morgan State University.

Cyves, LLC
- Developing commercial proof of concept of CRAFT intrusion detection cybersecurity system. Licensed technology from University of Maryland, Baltimore County.

Diagnostic anSERS Inc.
- Creating ink-jet printed sensors for authentication and trace containment detection. Licensed technology from University of Maryland, College Park.

EduMD
- Developing MileMarker: an easy-to-use, web-based, med-tech tracking system applicable to any procedure-based specialty to measure trainee competency and map changes in skill acquisition over time. Licensed technology from Johns Hopkins University.

emocha Mobile Health, Inc.
- Provides the mobile tools to engage and manage the patient and their safety. Licensed technology from Johns Hopkins University.

Glycomantra, Inc.
- Developing a galectin-3 antagonist for prostate cancer therapy.

Glyscend, Inc.
- Developing a minimally invasive solution for the treatment of T2 Diabetes. Licensed technology from Johns Hopkins University

Grip Boost, LLC.
- Developing a product that can restore old football gloves to ‘like-new’ tack without leaving residue on the ball. Licensed technology from University of Maryland, College Park.

Harpoon Medical
- Developing a minimally invasive surgical tool that surgeons can use to access the mitral valve in a beating heart, under image guidance via a small incision between the ribs, and repair it. Licensed technology from University of Maryland, Baltimore.

Hazel Analytics
- Developing a restaurant inspection data analytics software. Licensed technology from University of Maryland, College Park.

JPLC Associates
- Creating a unifying device for mechanical and dosimetric quality assurance measurements in radiation therapy. Licensed technology from Johns Hopkins University.

Living Canopies
-Building a patio umbrella that utilized flowering plants as the canopy. Licensed technology from University of Maryland, College Park.

Lyse-it LLC
- Lyse-it; A system for preparing cellular samples for genetic analysis. Licensed technology from University of Maryland, Baltimore Campus.

MedSense, LLC
- Developing a sensor made with biocompatible materials, is smaller, superior performance, and lower product costs than currently available. Licensed technology from University of Maryland, College Park.

MF Fire Benefic, LLC
- Producing a Mulciber Stove – an atuomated, ultra-clean wood stone. Licensed technology from University of Maryland, College Park.

MycoMed Technologies, LLC
- Developing a diagnostic test for detection of aspergillus infection and invasive aspergillosis. Licensed technology from Johns Hopkins University.

NanoDirect, LLC
- Commercialization of Refined Nanoelectronic Inks. Licensed technology from Johns Hopkins University.

Natsar Pharmaceuticals, Inc.
- Development of RK-33 as a Novel Therapy for Non-Small Cell Lung Cancer. Licensed technology from Johns Hopkins University.

N5 Sensors
- Developing an ultra-low profile, low-power, and smart sensor architecture for monitoring a variety of trace gases (toxic, explosive, corrosive) in air. Licensed technology from University of Maryland, College Park.

NexGen Forensic Sciences, LLC
- The gold standard for safe fetal paternity testing during pregnancy using maternal blood sample DNA. Licensed technology from Johns Hopkins University.

North American Wave Engine Corporation
- Developing a high-performance, low-noise pulsejet engine. Licensed technology from University of Maryland, College Park.

Octava LLC
- A System for Real-Time Audience Engagement in a Software as Service Model. Licensed technology from University of Maryland, Baltimore Campus.

Orablas, LLC
- RestEaze: Advanced ambulatory measures of leg movements Including Periodic Leg Movements During Sleep. Licensed technology from Johns Hopkins University.

Otomagnetics
- Working on the treatment of Otitis Media without puncturing the ear drum. Licensed technology from University of Maryland, College Park.

Pataigin
- Developing EndoPrint, a test that identifies microorganisms with unique speed and sensitivity. Licensed technology from University of Maryland, Baltimore.

PathOtraK
- Developing a way to reduce the Salmonella detection in less than 4 hours. Licensed technology from University of Maryland, College Park.

Rapid
- Development of a web and cloud-based software product for organ dosimetry of alpha emitters. Licensed technology from Johns Hopkins University.

React Labs
- Real-time polling platform. Licensed technology from University of Maryland, College Park.

respeQ, Inc.
- Developing a suite of products that uniquely monitor in-home respiratory function that initially relate to sleep disordered breathing and wirelessly transmit those outputs to a mobile diagnostic application platform. Licensed technology from Johns Hopkins University.

Revolve Biotechnologies, Inc
- Developing high-quality DNA mutant libraries for engineering high-value proteins. Licensed technology from Johns Hopkins University.

Second Write
- Creating a method for source code recovery. Licensed technology from University of Maryland, College Park.

Serenta Biotechnology, LLC
- Commercialization and development of a vaccine against staphylococcus aureus. Licensed technology from University of Maryland, Baltimore.

SilcsBio LLC
- Developing advanced molecular modeling software that enhances drug discovery. Licensed technology from University of Maryland, Baltimore.

SONAVEX Surgical
- Developing an ultrasound-based vascular monitoring system. Licensed technology from Johns Hopkins University

Tarsier Optics, Inc.
- A light weight, high resolution camera system for surveying and surveillance. Licensed technology from the University of Maryland, Baltimore Campus. Licensed technology from University of Maryland, Baltimore Campus.

Theraly Fibrosis, Inc.
- Optimization and validation of TLY012 treatment of systemic scleroderma. Licensed technology from Johns Hopkins University.

VakSea, Inc.
- Developing an oral vaccine for nervous necrosis virus. Licensed technology from University of Maryland, Baltimore County.

WebbCures, LLC
- Developing a diagnostic for assessing NKT cell function in cancer.


FUNDED UNIVERSITY PROJECTS

JOHNS HOPKINS UNIVERSITY
- Developing software for rehabilitation healthcare analytics & prediction (ReHAP) (Gourab)
- Developing a multicomponent inhibition of hypoxia inducible factor to treat ocular neovascularization (Green)
- Developing a minimally invasive theranostic device for brain neurooncology (Manbachi)
- Developing a novel biomarker and ELISA assay for determination of cognitive status in Alzheimer’s disease (Worley)
- Developing a therapeutic to prevent kidney toxicity in prostate cancer patients receiving PSMA-targeted radiotherapy (Slusher)
- Developing a device to more accurately target spine during lumbar punctures (LP) to collect cerebrospinal fluid(CSF) (Moghekar)
- Developing a method to use non-contrast-enhanced MRI and Perfusion index Mapping (Qin)
- Developing a drug, Ethoxyquin-6, for prevention of chemotherapy-induced peripheral neuropathy (Hoke)
- Develop a polyionic papillomavirus-like particles (VLP) for the treatment of prostate cancer (Viscidi)
- Development of Hypoxia Inducible Factor-1 with Polymeric Chitosan Nanoparticles to improve wound healing (Harmon)
- Developing the Corrie Health Digital Platform: Reinventing cardiac recovery (Martin)
- Developing Intra-ART: A novel platform for MRI-guided intra-arterial placement of therapeutic agents to treat brain tumors (Pearl)
- Developing a novel device for effective minimally invasive treatment for urethral strictures (Wright)
- Developing a cohesive robot-ultrasound probe for prostate biopsy (Stoianovici)
- Development of immunoswitch for treatment of metastatic melanoma: a novel immunomodulator approach (Schneck)
- Developing a halofuginone as a disease-modifying therapy for osteoarthritis (Cao)
- Developing a VLM-modified s-Ontak: a second-generation, Treg-depleting immunotherapy (Bishai)
- Developing a cardiac RF ablation lesion assessment system (Karmarkar)
- Developing a first non-invasive ELISA assay for pulmonary arterial hypertension (Everett)
- SMART surgical tools: optical coherence sensor guided microsurgical tools with enhanced surgical fun (Kang)
- “Smart” programmable digital stethoscope (Elhilali)
- Developing a novel blood/sputum diagnostic test for lung cancer (Brock)
- Developing a novel thyroid cancer specific biomarker panel (Umbricht)
- Developing a precision medicine approach for treating a subtype of severe pain called allodynia (mechanical pain)(Bosmans)
- Developing a new class of therapeutic compounds for the treatment of diarrhea predominant irritable bowel syndrome (IBS-D) (Barrow)
- Developing an injectable nanofiber-hydrogel composite for soft tissue reconstruction (Sacks)
- Developing a long-acting therapy for Parkinson’s Disease (Ko)
- Developing an Epigenetic based test for the prediction of postpartum depression in pregnant women (Kaminsky)
- Developing a 5-HT1A-Receptor: Biomarker stratification of patients with suicidal risk during treatment of pediatric depression (Kaplin)
- Developing the Renalert System, a monitor for real time renal perfusion which enables clinicians to prevent acute kidney injury (AKI) (Hogue)
- Repurposing of Cethromycin (QB101) for Malaria Prophylaxis (Sullivan)
- Developing a new, first-in-class therapeutic to treat a heritable form of retinal degeneration called Leber’s congenital amaurosis (LCA) (Bunz)
- Developing a new treatment for the autoimmune rheumatic disease, systemic sclerosis(SSc) (Lee)
- Developing a small molecule PSMA inhibitor to treat Inflammatory Bowel Disease (Hartman-Ph.2)
- Developing an imaging (FBnTP) agent as a biomarker for tumor aggressiveness and response to chemotherapy in early detection (Madar)
- Develop color-coded quantitative brain cancer mapping for real-time, cost-effective surgical guidance. (Li)
- Develop a therapeutic vaccine as a novel treatment for neuromyelitis optica (NMO) (Levy)
- Develop a potent drug with a novel mechanism for the treatment of leukemia and lymphoma (Slusher)
- Develop a novel tool for seizure localization in medically refractory epilepsy (Sarma)
- Developing bifunctional immunostimulatory antibodies for treatment of cancer (Bedi)
- Develop REMS: Robotic ENT Microsurgery System (Taylor)
- Develop codeDNA: Advanced Malware Variant Detection (Breiner)
- Developing biodegradable aAPC particles for cancer immunotherapy (Green)
- Developing a drug to reverse atherosclerotic heart disease in diabetic mice (Chatterjee)
- Develop an adaptive robotic platform for expandable, easy to program collaborative industrial robots (Hager)
- Developing a saliva based rapid diagnostic test for detection of asymptomatic carriers of the malaria parasite (Dinglasan)
- Improve delivery, enhance efficacy, and prolong glutaminase inhibitor drug levels in the tumor with the ultimate goal of improving outcomes for pancreatic cancer patients (Le)
- Developing LiFi enabled 3D Optical Imaging for collision safety and autonomous transportation (Torruellas)
- Improving computer-assisted craniomaxillofacial surgery (Gordon)
- Using cell permeable peptides derived from Pirt2 mutant protein to treat chronic pain (Dong)
- Developing a device that will reduce reoperation rates in breast conserving surgery. (Benkoski)
- Developing a blood test based on methylated gene markers for breast cancer. (Sukumar)
- Developing an inexpensive tool, called FastStitch, to improve the surgical suture process. (Nguyen)
- Creating a device to assess cardiac filling pressure for preventing re-hospitalization for heart failure. (Silber)
- Introduced a diagnostic method for rapid detection of significant coronary heart disease. (McVeigh)
- Developing a cancer targeting agent, which has special relevance in castration-resistance prostate cancer (In collaboration with University of Maryland, Baltimore County). (Laiho)
- Developing a device, called MouthLab, to enable the fast sampling of medical data. (Fridman)
- Developing a new lotion to augments wound healing, improves healing skin quality and reduces scar size. (Walston)
- Developing a polymeric fore sensor that is used with middle ear titanium prostheses to provide feedback to the surgeon. (Francis)
- Developing non-invasive quantitative CT imaging-based alternative that will provide accurate and rapid determination of the functional significance of coronary artery disease. (Lardo)
- Evaluating the efficacy and toxicity of artemisinin dimers in a mouse model and to select the lead   dimer for further development towards clinical studies in humans. (Boger)
- Develop a prototypic nanoparticle based system to mediate redirected lysis by human antigen-specific cytotoxic T lymphocytes, CTL, to tumor cells that would otherwise not be recognized. (Schneck)
- Developing a technology to use autologous volar fibroblasts to create new thick skin at the stump site for amputees. (Kang)
- Commercialize novel chemical exchange saturation transfer (CEST) magnetic resonance imaging  (MRI) biosensors. (van Zijl)
- Developing a peptide-based therapy for acute and chronic diahrreal diseases. (Zachos)
- Developing a more effective treatment for seizures using amino acid therapy. (Hartman)
- Developing a low cost, high speed, wide dynamic range, software configurable, multimodel imaging sensor. (Rizk)

MORGAN STATE UNIVERSITY
- Developing SUMZ: A stormwater utility management system (Hunter)
- Developing LightTrax: a building occupant lighting tracking system (Nyarko)
- Developing technology that offers a cost-effective and environmental friendly alternate to produce biofuel using naturally available sea water and the sun’s energy. (Early Charm Ventures-Ph.2)
- Developing the iCrystal System and new crystallization platforms for rapid drug treatment. (Aslan-Ph.2)

UNIVERSITY OF MARYLAND BALTIMORE
- Developing a diagnostic for non-small cell lung cancer (Jiang)
- Developing next-generation multi-specific antibody therapeutic (Li)
- Developing a novel bifunctional antibody for lung cancer therapy (Ren)
- Developing a novel transRectal Focal Abdominal Cooling (rFAC) device for the treatment of IRI and SIRS (Hu)
- Developing a blood test for the early detection of lung cancers based on newly-discovered sprRNAs (Mei)
- Using Synthetic Inhibitory Mucin Protecting Lung Epithelia (SIMPLE) technology to treat pseudomonas lung infections (Lillehoj)
- Developing a first-in-class therapy for sepsis (Vasta)
- Developing a portable deficit-adjusted ankle robot for neurologically disabled populations (Macko)
- Optimization and Validation of a Novel Immunotherapy against Clostridum difficile Infection (CDI). (Feng)
- Developing a novel system for recombinant protein expression. (In collaboration with University of Maryland, College Park) (Robb)
- Refining and validating the first universal cancer immunotherapy, At-CAR (Anti-tag Chimeric Antigen Receptor). (Davila-Ph.2)
- Developing a new target and approach to antibiotic therapy (Wilks)
- Using magnetic nanoparticles for the treatment of dental disease (Masri)
- Developing VNLG-152 as a novel targeted therapy for triple negative breast cancer (Njar)
- Developing a technology for Alzheimer’s disease therapy that targets an inflammatory pathway in asymptomatic and symptomatic patients. (Zimmer)
- Develop a method to rapidly assess the function of NKT cells in cancer patients (Webb)
- Developing anti-thrombosis antibody product to improve clinic treatments (Xu)
- Developing a novel hybrid mesh for the treatment of pelvic organ prolapse. (ZSX Medical-Ph.2)
- Developing a technology, called RelaxDetect, which can detect biopharmaceutical aggregation via water relaxation in sealed vials. (Bruce Yu)
- Develop a thermal endoscope for laparoscopy. This technique will reduce serious intraoperative complications by over 50%. (Pearl)
- Commercialization of an Inflammatory Bowel Disease (IBD) diagnostic based on a microbiome signature technology. (ITVMD-Ph.2)
- Developing an interactive web-based software that will be commercialized for detecting and addressing parental psychosocial risk factors for child abuse/neglect within healthcare settings. (Dubowitz)
- Develop a unique opioid analgesic with reduced tolerance. (Coop)
- Developing a topical cream for treatment of cervical intraepithelial neoplasia. (Khanna)

UNIVERSITY OF MARYLAND BALTIMORE COUNTY
- LifePower: a self charging power source for implantable devices (Slaughter)
- SolarSafe: a long-lead-time forecaster of solar storms (Savani)
- Developing ‘substrate-cage: devices for novel enzyme discovery (Gardner)
- Developing small molecule pyrimidines – potent anticancer therapeutics (Seley-Radtke)
- Developing a commercialization plan for CRAFT cybersecurity system (ITVMD-Ph.2)
- Develop an immunotherapy drug (BiTE) for the treatment of cancer. (Ostrand-Rosenberg)
- Developing an App for real-time audience enhancement and music education during music presentation and concerts. (Dusman-Ph.2)
- Biomarker discovery and validation for Kinase Inhibitors (Bieberich)
- Developing a geared infinitely variable transmission with minimal speed fluctuation. (Zhu)
- Working to increase food safety and agricultural productivity through innovative feed additives. (MycoInnovation)
- Developing soluble CD80 (CD80-Fc) as a therapeutic agent for the treatment of cancer. (Ostrand-Rosenberg)
- Develop and evaluate the efficacy of a recombinant NNV (Nervous necrosis virus) vaccine. (Vakharia)
- Produce a bioamended activated carbon pellet seeded with PCB- degrading microorganisms to reduce the concentration of polychlorinated biphenyls (PCBs) in sediments. (Sowers)
- Developing a sensing system comprising of ultra-low cost textile-based nonrigid capacitive sensor arrays and inertial sensors that allow individuals with upper extremity paralysis to control their appliances and security systems remotely. (Banerjee)

UNIVERSITY OF MARYLAND COLLEGE PARK
- Developing a recurrent processing unit (RPU) for high performance computing (Lathrop)
- Building-scale weather and energy forecast service (BuildECast) for electricity savings (Jin)
- Developing novel polyphosphazene technology for stabilizing protein therapeutics (Andrianov)
- Developing targeted enzymes for effective treatment of lysosomal disorders (Muro)
- Developing drought-tolerant crop cultivars with improved water-use efficiency (Xiao)
- Pitch Perfect electronic home plate for baseball and softball (Davis)
- Constructing a HorseSHU Unmanned Aerial System (Valente)
- Develop QUANTITY: A novel analysis kit for protein drug development (In collaboration with Johns Hopkins University). (Li)
- Developing an integrated power electronic charger/converter for plug-in electric vehicles. (Khaligh)
- Developing an efficient mucosal vaccination mediated by the Neonatal Fc Receptor. (Zhu)
- Creating hemostatic bandages based on a new biocompatible polymer (In collaboration with University of Maryland Baltimore). (Raghavan)
- Developing and testing protocols for scour sensing post deployment. (Tauros-Ph.2)
- Developing novel acyclic cucurbituril molecular containers as broad spectrum reversal agents for neuromuscular block agents used during surgery. (Isaacs)
- Developing a clinical assay that would provide a tool to improve time to diagnose and monitor disease progression in ALS and possibly other neuromuscular diseases (In collaboration with University of Maryland, Baltimore). (Chin)
- Developing a vaccine against a significant swine pathogen, procine reproductive and respiratory syndrome virus (PRRSV). (Zhang)
- Developing 2D hyperspectral imaging techniques for manufacturing yield and device failure analysis for photovoltaic cells and LEDs. (Bartolo)
- Develop a new technology for the production of liposomal nanoparticle drugs in a unique continuous-flow manufacturing process. (DeVoe)
- Develop data analysis tools on a user-friendly web interface and customize them for a variety of clients ranging from national chain restaurants to other establishments and local health departments in searching the existing nationwide food safety inspections database. (Bederson)
- Developing a novel, generalized approach to the formulation of vaccines against Gram-negative pathogens (In collaboration with University of Maryland, Baltimore). (DeShong)
- Customize Behavioral Activation Treatment for Depression (BATD) for a mobile platform to be used by clinicians and their patients by creating a BATD mobile application to be used in conjunction with therapy. (Lejeuz)
- Developing a non-invasive way to evaluate the quality of a donor kidney known as kidney viability assessment system (KVAS). (Chen)